Features of the cognitive sphere in patients with a mixed episode of bipolar affective disorder

Keywords: bipolar affective disorder, mixed episode, neurocognitive impairment

Abstract

Background. Data of various meta-analyzes confirm that the majority of patients with bipolar affective disorder (BAD) have neurocognitive dysfunction, even during remission. According to the latest research, disturbed domains with moderate to pronounced changes are attention, verbal learning and memory, as well as executive functions, whereas premorbid intelligence may remain unchanged. The main body of research is devoted to the study of cognitive impairment in the first episode of BAD, in manic, depressive episodes and euthymia. At the same time, the features of cognitive dysfunction in mixed forms of biologically active substances remain insufficiently studied.

Objective – to study the characteristics of the cognitive sphere in patients with a mixed episode of BAD.

Materials and methods. With the help of battery tests (a test to memorize ten unrelated words; Rey-Osterreith Complex Figure Test; Verbal Fluency Test Digit Symbol Substitution Test; Trail making test), the cognitive functions of 25 patients with mixed episodes, 16 patients with manic episodes, and 15 patients with depressive episode of BAD.

Results. Cognitive impairments were identified in all patients, regardless of the type of affective symptoms, in the form of a wide range of psychopathological phenomena, which are more pronounced in patients with a mixed episode BAD. The peculiarities of the phenomenological structure of cognitive impairment in patients with mixed phase BAD manifest themselves in the form of: a more pronounced deterioration of verbal memory, speed of information processing; more pronounced violations of spatial representations, impairment of visual memory, verbal associative performance and executive functions; reduction of attention and violations of its distribution.

Conclusions. The findings suggest that the presence of depressive symptoms in the structure of mixed affect plays a dominant role in the formation of these disorders.

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Published
2019-09-18
How to Cite
Pidkorytov, V. S., Syerikova, O. I., Ukrainskyi, S. O., Skrynnyk, O. V., & Serikova, O. S. (2019). Features of the cognitive sphere in patients with a mixed episode of bipolar affective disorder. Archives of Psychiatry, 25(3), 124-129. https://doi.org/10.37822/2410-7484.2019.25.3.124-129